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Abstract@#Bisphenols (BPs), which are mainly used in the production of polycarbonates and epoxy resins, are common endocrine disruptors (EDCs) in natural environments. Human mainly exposes to BPs via ingestion and skin. Previous studies have deteted BPs in human urine, serum, and milk samples, and children and pregnant women have a high level of exposure to to BPs. Based on international and national publications pertaining to BPs since 2009, this review describes the exposure to BPs in human urine, serum, and milk and summarizes neuroendocrine dysfunctions, oxidative stress injury and epigenetics changes caused by BPs, so as to provide insights into reducing the exposure to and health risk of BPs.
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Benzophenone-3 is the most widely used benzophenone type UV filter, which is lipophilic, light stable and bioaccumulative. Benzophenone-3 is widely present in environmental waters and can be detected in humans. Its potential toxicity (especially endocrine disruption) has attracted people's attention. There are a lot of related data on the exposure of benzophenone-3 in the environment and humans from foreign literatures, but there are few studies on related aspects in China. In the view of widespread presence of benzophenone-3 and its endocrine disruption, future researches should focus on its potential toxicity to the population including endocrine disruption and the mechanisms.
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A review study was conducted to examine the adverse effects of styrene, styrene mixtures, or styrene and/or styrene mixtures and noise on the auditory system in humans employed in occupational settings. The search included peer-reviewed articles published in English language involving human volunteers spanning a 25-year period (1990–2015). Studies included peer review journals, case–control studies, and case reports. Animal studies were excluded. An initial search identified 40 studies. After screening for inclusion, 13 studies were retrieved for full journal detail examination and review. As a whole, the results range from no to mild associations between styrene exposure and auditory dysfunction, noting relatively small sample sizes. However, four studies investigating styrene with other organic solvent mixtures and noise suggested combined exposures to both styrene organic solvent mixtures may be more ototoxic than exposure to noise alone. There is little literature examining the effect of styrene on auditory functioning in humans. Nonetheless, findings suggest public health professionals and policy makers should be made aware of the future research needs pertaining to hearing impairment and ototoxicity from styrene. It is recommended that chronic styrene-exposed individuals be routinely evaluated with a comprehensive audiological test battery to detect early signs of auditory dysfunction.
Subject(s)
Adult , Animals , Humans , Administrative Personnel , Healthy Volunteers , Hearing Loss , Mass Screening , Noise , Peer Review , Public Health , Sample Size , StyreneABSTRACT
Abstract Great response variability caused by genetic and/or environmental factors has been observed among organisms exposed to hazardous chemicals. This subject has been a topic of intense discussion in the USA since President Obama announced support for an “era of precision medicine”, which consists in the inclusion of genetic data of patients in the treatment design, imposing a new approach to risk assessment. Personalized evaluation must consider the phenotypic factors of an individual. Among the markers that have been developed to evaluate any alteration in the structure or function of organisms, biomarkers of susceptibility are of great importance because they indicate the natural characteristics of a given organism which make it more sensitive to a specific adverse effect or disease, or more responsive to exposure to a specific chemical/drug. The ‘-omics’ technologies provide an insight into the relationship between chemical effects and molecular mechanisms of action. These technologies are the pillars for a personalized toxicology and precision medicine. Predictive toxicology requires a more comprehensive knowledge on specific individual factors or susceptibilities predisposing to diseases, enabling personalized risk assessment and adequate medical treatment.
Resumo Há uma grande variabilidade nas respostas observadas entre os organismos expostos a uma substância química perigosa. Essa variabilidade é causada por causas genéticas e / ou ambientais. Esse assunto tem sido intensamente discutido, mesmo nos Estados Unidos, desde que o presidente Obama anunciou o apoio a uma “era da medicina de precisão”, a qual consiste na inclusão de dados genéticos do paciente no projeto do tratamento, impondo uma nova abordagem para avaliação de risco. A avaliação personalizada deve considerar fatores fenotípicos de um indivíduo. Entre os biomarcadores que foram desenvolvidos para avaliar qualquer alteração da estrutura ou função do organismo, os biomarcadores de susceptibilidade têm uma grande importância, uma vez que indicam as características naturais de um dado organismo, que o tornam mais sensíveis a um efeito ou doença adversa específica ou em resposta a uma determinada exposição. As tecnologias “ômicas” permitem a compreensão da relação entre os efeitos químicos e dos mecanismos moleculares de ação. Essas tecnologias “ômicas” são os pilares para a toxicologia personalizada e para a medicina de precisão. Toxicologia preditiva exige uma melhor compreensão dos fatores ou susceptibilidades individuais específicas predisponentes a doenças, permitindo uma avaliação de riscos personalizada e um tratamento médico adequado.
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INTRODUCTION: The cycling activity has increased in recent years, either as a means of leisure or physical activity or as means of transport. Discomfort is one of the main complaints for cyclists, especially when related to the type o pavement they use while riding. This work presents a study of measurement and evaluation of human exposure to hand-arm vibration in the leisure cyclist activity in different pavements in order to classify according to vibration discomfort and to vibration injury risk. METHODS: Vibration measurements are performed for three pavement types, asphalt (AS), precast concrete slab (PC), and interlocking concrete blocks (BI), using two bicycle models (time trial speed racing bike, S and mountain bike, MB), and cyclists with different physical characteristics. It is performed a quantitative analysis of each configuration - pavement type × bike model × cyclist - where the daily vibration exposure A(8) is evaluated, as defined in ISO 5349-1 Standard, for 2h daily exposure. It is also evaluated the maximum daily exposure in order to reach limit values, as defined by Directive 2002/44/EC. RESULTS: Based on a subjective analysis (survey), it is evaluated the comfort degree for vibration exposure for each tested pavement, according to a survey within cyclists. Finally, the results are compared using both quantitative and subjective analysis. CONCLUSIONS: Not surprisingly, it has been noticed that the most comfortable pavement type is the asphalt pavement (AS), followed by the precast concrete pavement (PC) and by the interlocking concrete blocks pavement (BI), confirming the opinion pool within cyclists. As a new finding, for some pavement types, bikes and daily journey activities, the vibration levels may reach health limit levels which justify the originality of the work and the importance as guidance for healthy public decisions for new cycle paths.
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Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.
Bisfenol A (BPA) é um dos produtos químicos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinética do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco.
Subject(s)
Humans , Air Pollutants/analysis , Environmental Exposure/analysis , Environmental Monitoring , Phenols/analysis , Air Pollutants/blood , Air Pollutants/urine , Environmental Monitoring/methods , Forecasting , Phenols/blood , Phenols/urine , Research/trendsABSTRACT
Methylmercury is a hazardous substance that is of interest with regard to environmental health, as inorganic mercury circulating in the general environment is dissolved into freshwater and seawater, condensed through the food chain, ingested by humans, and consequently affects human health. Recently, there has been much interest and discussion regarding the toxicity of methylmercury, the correlation with fish and shellfish intake, and methods of long-term management of the human health effects of methylmercury. What effects chronic exposure to a low concentration of methylmercury has on human health remains controversial. Although the possibility of methylmercury poisoning the heart and blood vessel system, the reproductive system, and the immune system is continuously raised and discussed, and the carcinogenicity of methylmercury is also under discussion, a clear conclusion regarding the human health effects according to exposure level has not yet been drawn. The Joint FAO/WHO Expert Committee on Food Additives proposed to prepare additional fish and shellfish intake recommendations for consumers based on the quantified evaluation of the hazardousness of methylmercury contained in fish and shellfish, methylmercury management in the Korea has not yet caught up with this international trend. Currently, the methylmercury exposure level of Koreans is known to be very high. The starting point of methylmercury exposure management is inorganic mercury in the general environment, but food intake through methylation is the main exposure source. Along with efforts to reduce mercury in the general environment, food intake management should be undertaken to reduce the human exposure to methylmercury in Korea.
Subject(s)
Animals , Humans , Environmental Exposure , Fishes/metabolism , Food Chain , Mercury Poisoning, Nervous System/etiology , Methylmercury Compounds/chemistry , Neurons/drug effects , Oxidative Stress/drug effects , Public Health , Reproduction/drug effects , Thymocytes/cytologyABSTRACT
The aim of this study was to develop a reliable dietary questionnaire to assess human exposure to food-borne hazards. Eleven food-borne hazards were chosen as a priority control list through a literature review and advisory committees. The 11 food-borne hazards were phthalate, aflatoxin, bisphenol A, polycyclic aromatic hydrocarbons, dioxin, polychlorinated biphenyls, mercury, lead, cadmium, arsenic, and acrylamide. The characteristics, exposure level, and paths of these hazards were reviewed, and questionnaire items were identified to assess human exposure from the literature. A questionnaire was developed for each selected food based on its characteristics. Based on the items in the individual questionnaires, a comprehensive questionnaire, which contained demographic characteristics, job information, socioeconomic factors, health related lifestyles, and dietary behaviors, was developed. A 99-item food frequency questionnaire (FFQ) to assess food-borne hazard exposure was also developed. The FFQ included frequency of food intake during the previous year, container type for purchasing and storing food, and cooking method. The questionnaire developed in this study could be applied to assess dietary factors during an exposure assessment of food-borne hazards in a large population. A validation study for the questionnaire is needed before applying it to surveys.
Subject(s)
Humans , Acrylamide , Advisory Committees , Aflatoxins , Arsenic , Benzhydryl Compounds , Cadmium , Cooking , Eating , Life Style , Phenols , Phthalic Acids , Polychlorinated Biphenyls , Polycyclic Aromatic Hydrocarbons , Surveys and Questionnaires , Socioeconomic FactorsABSTRACT
The current state of environmental pollution by persistent bio-accumulative and toxic substances (PBTS) in the Chilean food and population is practically unknown. This short communication aims to open the discussion on the need to assess the level of contamination of PBTS derived from foods consumed by the Chilean population considering diet as one of the main route of exposure.
El estado actual de la contaminación ambiental con Sustancias Persistentes Bioacumulables y Toxicas (PBTS) en los alimentos y población Chilena es prácticamente desconocida. Por este motivo esta comunicación corta tiene como objeto abrir la discusión sobre la necesidad de evaluar el nivel de contaminación por PBTS proveniente de los alimentos que consume la población Chilena, considerando a la dieta como una principal vía de exposición.